Fujifilm dünyayı daha iyi, daha sağlıklı ve daha ilgi çekici bir yer hâline getirmeye yardımcı oluyor.
PuraStat is a slightly viscous solution of synthetic peptides. When in contact with blood, the synthetic peptide self-assembles into a 3-dimensional matrix which rapidly coats the bleeding point leading to haemostasis.
PuraStat can be used to achieve haemostasis during endoscopic intervention in case of bleeding from small blood vessels and oozing from capillaries of the GI tract following endoscopic resection procedures.
PuraStat is also indicated for the reduction of delayed bleeding by 50 % following gastrointestinal endoscopic submucosal dissection (ESD) procedures in the colon.1
|PuraStat (n=76)||Control2 (n=202)|
|Rectum||25/76 (32.9%)||69/202 (34.2%)|
|Location of lesions||Sigmoid/descending||16/76 (21.1%)||72/202 (35.6%)|
|Transverse/ascending||26/76 (34.2%)||40/202 (19.8%)|
|Caecal||9/76 (12%)||20/202 (9.9%)|
|Median lesion size (mm)||32||40|
|Number of bleeds (n,%)||1/76 (1.3%)||6/202 (3.0%)|
Bleeding from small blood vessels and oozing from capillaries of the GI tract following ESD in the colon.
|1.||Remove as much blood as possible from haemorrhagic site.|
|2.||Apply PuraStat as close as possbile to the bleeding point.|
|3. ||Continue to apply PuraStat by moving the endoscopic applictor until the product exceeds the margins of the lesion. Practical experience suggests to work from distal to proximal (Prof. Bhandari).|
|4. ||When potentially re-applying; go through the already present material and apply PuraStat as close as possible to the bleeding point. Note: PuraStat in the lumen of the catheter ('dead volume') can be pushed out by e.g. air.|
1 Subramaniam S., Kandiah K., Fujimoto A., Yahagi N., Toshio Uraoka T., Bhandari P. Minimising the risk of delayed bleeding in colonic endoscopic submucosal dissection: Is there a role for a novel haemostatic peptide? United European Gastroenterology Journal 2017; 5 (Supplement 1)
2 In the control group neither PuraStat nor other techniques were used.