Україна

PuraStat

PuraStat - Haemostat for ESD in the colon

About PuraStat

PuraStat is a slightly viscous solution of synthetic peptides. When in contact with blood, the synthetic peptide self-assembles into a 3-dimensional matrix which rapidly coats the bleeding point leading to haemostasis.

PuraStat can be used to achieve haemostasis during endoscopic intervention in case of bleeding from small blood vessels and oozing from capillaries of the GI tract following endoscopic resection procedures.

Transparent

  • Does not block field of view, continue with procedure
  • Bleeding status can be checked
  • Can be reapplied

Versatile

  • Applicable to narrow spaces
  • Can be used in combination with coagulation, clips etc.

User-friendly

  • Ready to use in pre-filled syringe
  • Easy to deliver and handle

The haemostat approved to reduce delayed bleeding following ESD in the colon

PuraStat is also indicated for the reduction of delayed bleeding by 50 % following gastrointestinal endoscopic submucosal dissection (ESD) procedures in the colon.1 

PuraStat (n=76) Control(n=202)
Age (years) 69.9 72.3
Gender (M:F) 44:32 123:79
Rectum 25/76 (32.9%) 69/202 (34.2%)
Location of lesions Sigmoid/descending 16/76 (21.1%) 72/202 (35.6%)
Transverse/ascending 26/76 (34.2%) 40/202 (19.8%)
Caecal 9/76 (12%) 20/202 (9.9%)
Median lesion size (mm) 32 40
Number of bleeds (n,%) 1/76 (1.3%) 6/202 (3.0%)

PuraStat is easy to deliver and to handle

Bleeding from small blood vessels and oozing from capillaries of the GI tract following ESD in the colon.

1. Remove as much blood as possible from haemorrhagic site.
2. Apply PuraStat as close as possbile to the bleeding point.
3.
Continue to apply PuraStat by moving the endoscopic applictor until the product exceeds the margins of the lesion. Practical  experience suggests to work from distal to proximal (Prof. Bhandari).
4.

When potentially re-applying; go through the already present material and apply PuraStat as close as possible to the bleeding point. Note: PuraStat in the lumen of the catheter ('dead volume') can be pushed out by e.g. air.
5. Haemostasis achieved

During UEG week 2019 Prof. Pradeep Bhandari (University of Portsmouth, Solent centre for Digestive Diseases, Queen Alexandra Hospital Portsmouth) shared his experience with PuraStat.


1
Subramaniam S., Kandiah K., Fujimoto A., Yahagi N., Toshio Uraoka T., Bhandari P. Minimising the risk of delayed bleeding in colonic endoscopic submucosal dissection: Is there a role for a novel haemostatic peptide? United European Gastroenterology Journal 2017; 5 (Supplement 1)

2 In the control group neither PuraStat nor other techniques were used.