—a company developing, manufacturing and marketing iPS cell-derived differentiated cells
FUJIFILM Corporation (President: Shigehiro Nakajima) has announced that it will establish Cellular Dynamics International Japan Co.,Ltd.(hereinafter “CDJ”), a company for developing, manufacturing and marketing differentiated cells derived from induced pluripotent stem cell (iPS cell)* on October 1 for building iPSC business to support drug discovery in Japan. CDJ will initially import iPS cell-derived differentiated cells designed for drug discovery support, manufactured by the U.S.-based Fujifilm Group company, Cellular Dynamics International, Inc. (CEO Kazuyoshi Hirao, headquartered in Madison, Wisconsin; hereinafter “CDI”), and market them to universities, research institutes and private enterprises in Japan.
Currently, animal testing is conducted in the development of innovative drugs to confirm candidate drugs' efficacy and safety, and this is followed by clinical trials conducted on human subjects. However, since the development of many of such drugs that have passed animal testing becomes halted in the stage of human clinical trials, there is a growing market need for a way of confirming efficacy and safety on human cells before clinical trials can be initiated. Amidst this market sentiment, there has been a global trend towards applying iPS cells, which has the capacity for infinite reproduction and differentiation, to the field of drug discovery. In Japan, various pharmaceutical companies have partnered with numerous government research institutes to examine the use of iPS cell-derived differentiated cells on safety assessment for pharmaceutical development. In particular, efforts are being made to standardize safety assessment, using iPS cell-derived cardiomyocytes.
In May this year, Fujifilm acquired CDI, a global leader in the development and manufacturing of iPS cells. CDI leads the iPS cell business, already supplying numerous users including large pharmaceutical companies with high-quality iPS cell-derived differentiated cells in 12 types for drug discovery assistance including cardiomyocytes, neurons and hepatocytes as well as custom-made iPS cell-derived differentiated cells.
Fujifilm is setting up CDJ in Japan so as to supply CDI's iPS cell-derived differentiated cells and custom-made iPS cell-derived differentiated cells. CDJ also plans to set up a manufacturing and R&D base in Tonomachi (Kanagawa, Japan), which is designated as a National Strategic Special Zone** and an International Strategic Zone***. The site will be used to identify user needs on the quality and other properties of iPS cell-derived differentiated cells, and actively take on joint research with universities, research institutes and private enterprises to develop iPS cell-derived differentiated cells that can contribute broadly to the field of drug discovery support including chemical compound exploration, disease research and pharmacological evaluation. In the future, advanced production technologies, nurtured through Fujifilm's photographic film development, will be applied for mass production and stable distribution of high-quality iPS cell-derived differentiated cells in Japan.
Fujifilm has developed recombinant peptide (RCP)*4, which has excellent biocompatibility and can be processed into various shapes, as a “scaffold*5” material suitable for creating 3D cell structures. In the future, RCP can be used to build 3D-structured cells to enable more advanced pharmaceutical assessment in drug discovery assistance. Also in the field of regenerative medicine, where iPS cell application is anticipated, Fujifilm's high-functional material technologies and engineering technologies can be combined with CDI's iPS cell-related technologies / know-how and Fujifilm Group company Japan Tissue Engineering's cell production technologies for cell therapy for a synergistic effect, contributing to the establishment of the regenerative medicine industry.
|Company name||Cellular Dynamics International Japan Co.,Ltd.|
|Head office location||Minato-ku, Tokyo|
|Capital||100 million yen|
|Representative Director and President||Toshikazu Ban|
|Business description||Development, manufacturing and marketing of iPS cell-derived differentiated cells|
Fujifilm Corporation is a wholly-owned subsidiary of Fujifilm Holdings Corporation.